IGF-1 LR3 1mg

IGF-1 LR3 (Long-R3 Insulin-like Growth Factor 1) is a synthetic analog of human IGF-1 described in the literature as an 83-amino-acid peptide (MW ~9,200 Da) that combines two strategic modifications:

Documented molecular modifications:

• Arg³ substitution → reduced affinity for IGFBP-3/IGFBP-5 binding proteins documented in biochemical studies
• 13-amino-acid N-terminal extension derived from porcine growth hormone
• Extended plasma half-life described in the literature (~20-30 hours vs. 12-15 min native IGF-1)
• Affinities for the IGF-1 receptor are conserved in in vitro models.

Signaling pathways described in the literature:

1. IGF-1R Receptor (tyrosine kinase):

• IRS-1/IRS-2 activation documented in biochemical studies
• PI3K/Akt/mTORC1 cascade reported as the main protein synthesis pathway
• MAPK/ERK1/2 associated with cell proliferation in the literature

2. Reported cellular mechanisms (preclinical):

• Muscle satellite cell activation (Pax7+/MyoD+) in murine models
• FOXO inhibition/proteolytic atrophy documented in in vitro studies
• GLUT4-mediated glucose uptake in myocytes described in the literature

The scientific literature documents IGF-1 and its analogs in multiple experimental models:

• Tomas FM et al., Endocrinology 1993 (PMID 8462469): LR3-IGF-1 analogs in rat models showed anabolic effects on muscle protein synthesis
• Adams GR, Br J Sports Med 2002 (PMID 11916898): Review documents the role of IGF-1 in muscle hypertrophy induced by mechanical overload
• Philippou A et al., In Vivo 2007 (PMID 17436567): IGF-1 isoforms in post-exercise muscle repair in experimental models
• Frystyk J, Best Pract Res Clin Endocrinol Metab 2010 (PMID 20620540): Review on IGF-1 Biology and Synthetic Analogs

Research material only. No FDA-approved human use. All information is provided for educational and scientific literature reference purposes.

• Identification: IGF-1 LR3 (Long-R3 Insulin-like Growth Factor 1)
• Structure 83 amino acids · MW ~9,200 Da
• Modifications Arg³ + N-terminal extension of 13 aa
• Vial 1 mg lyophilized
• Purity >98% by HPLC
• Conservation refrigerated lyophilized 2-8°C · reconstituted use within 28 days

Material intended exclusively for scientific research.

Not for human consumption. No FDA-approved human use. Information is provided for educational and reference purposes to the published scientific literature.