Glutathione 600mg

Glutathione 600mg

Endogenous Tripeptide · Master Antioxidant · Phase II Detox · Research Only

What is it and how does it work?

Glutathione (GSH) is an endogenous tripeptide (γ-L-glutamyl-L-cysteinyl-glycine) synthesized in the liver, described in the literature as the master intracellular antioxidant. Its thiol group neutralizes ROS, peroxynitrite, and hydroxyl radicals in biochemical studies, and it acts as an obligate substrate of glutathione-S-transferase (GST) in phase II hepatic conjugation documented in experimental models. It regenerates oxidized vitamins C and E, maintaining the cellular redox cycle (Lu SC 2013, PMID 22995213).

The clinical research literature documents exogenous glutathione mostly IV (300–2400 mg) due to poor oral bioavailability (Allen J, Bradley RD, J Altern Complement Med 2011, PMID 21875351). Research studies: Honda Y et al., BMC Gastroenterol 2017 (PMID 28789631) reported oral GSH in NAFLD; Sechi G et al., Prog Neuropsychopharmacol Biol Psychiatry 1996 (PMID 8888107) documented IV GSH in early Parkinson's. Research material only — no FDA-approved human use.

Reconstitution

• Vial 10 mg lyophilized
• Bacteriostatic water: 3 ml (compressed — physical maximum of the vial; the standard rule would give an unworkable 120 ml)
• Resulting concentration: 200,000 mcg/ml = 200 mg/ml
• Per unit U-100: 2,000 mcg = 2 mg · verificación: 200,000 ÷ 100 = 2,000 mcg/u ✓
• Conservation Refrigerated 2–8°C · use within 28–30 days · protect from light (GSH oxidizes to GSSG with light/air) · discard if it turns yellow
• Performance Equivalent volume: 200 U-100 units per reconstituted vial

Documented evidence in research literature

Combinations reported in literature

• GSH + NAD+ en literatura preclínica: mecanismos independientes — GSH neutraliza ROS, NAD+ alimenta sirtuinas y reparación mitocondrial.
• GSH + Vitamin C: biochemical literature documents GSSG → GSH regeneration by vitamin C (Lenton 2003, PMID 12791621), extending the half-life of circulating glutathione.
• GSH + Alpha Lipoic Acid: the literature reports recycling of GSH/vit C/vit E by ALA and crossing of the blood-brain barrier (Packer 1995, PMID 7649494).
• GSH + GlyNAC (oral precursors): translational literature documents increased endogenous synthesis (Kumar P et al., Clin Transl Med 2021, PMID 33538908).

Practical notes

• 600 mg vial with 3 ml BAC reconstitution (physical maximum of the vial). Concentration 200 mg/ml = 2 mg/u. Standard rule unworkable: compression required.
• Light protection required: GSH auto-oxidizes to GSSG on contact with air/light. Wrap the reconstituted vial in foil. Discard if the solution turns yellow.
• The SubQ route is NOT the standard route in the clinical research literature (mostly IV, nebulized or liposomal oral). Research material only.

Contraindications and precautions

• Research material only. No FDA-approved human use. The literature reports theoretical cautions (bronchospasm with nebulized GSH, PMID 9032190; interaction with cisplatin). Not for human use.

Research material only. No FDA-approved human use. This product is intended for scientific research purposes in controlled laboratory settings only. It is not a drug. Not for human or animal administration, therapeutic use, or diagnostic use.