Epithalon 10mg

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), presented as a 10 mg research lyophilized powder per vial.

Signaling pathways documented in literature:

• Telomerase activation (hTERT): Cellular models document induction of telomerase activity and telomere elongation in cultured human fibroblasts
• Circadian modulation: Preclinical rodent studies describe normalization of melatonin secretion and circadian rhythm
• Gene Regulation / Chromatin Experimental literature reports effects on gene expression and chromatin structure (perinuclear heterochromatin).

• Khavinson VK et al., Neuro Endocrinol Lett 2003 (PMID 14523363): Epithalon in models of cellular aging and telomerase activation
• Anisimov VN et al., Mech Ageing Dev 2003 (PMID 12782392): Epithalon in murine models of longevity and carcinogenesis
• Khavinson VK, Bull Exp Biol Med 2002 (PMID 12937682): Effects of the tetrapeptide on telomerase activity in human cell cultures

Research material only. No human FDA-approved use. All information is provided for educational purposes and reference to scientific literature.

• Identification: Epithalon (AEDG) — tetrapeptide Ala-Glu-Asp-Gly
• Presentation 10 mg lyophilized per vial
• Purity >98% by HPLC
• Laboratory reconstitution: 2 mL of bacteriostatic water → 5,000 mcg/mL
• Conservation Lyophilized refrigerated 2-8°C · protect from light · use within 28 days after reconstitution

Material for scientific research purposes only.

Not for human consumption. No FDA approved human use. Information is provided for educational and reference purposes to published scientific literature.