{"id":1462,"date":"2026-05-27T09:59:01","date_gmt":"2026-05-27T14:59:01","guid":{"rendered":"https:\/\/elyxaminos.com\/producto\/igf-1-lr3-1mg\/"},"modified":"2026-09-04T21:34:55","modified_gmt":"2026-09-05T02:34:55","slug":"igf-1-lr3-1mg","status":"publish","type":"product","link":"https:\/\/elyxaminos.com\/en\/producto\/igf-1-lr3-1mg\/","title":{"rendered":"IGF-1 LR3 1mg"},"content":{"rendered":"
\n
\n\ud83d\udd39 IN-DEPTH SCIENTIFIC PROFILE<\/summary>\n

IGF-1 LR3 (Long-R3 Insulin-like Growth Factor 1) is a synthetic analog of human IGF-1 described in the literature as an 83-amino-acid peptide (MW ~9,200 Da) that combines two strategic modifications:<\/span><\/p>\n

Documented molecular modifications:<\/b><\/p>\n

    \n
  • Arg\u00b3 substitution \u2192 reduced affinity for IGFBP-3\/IGFBP-5 binding proteins documented in biochemical studies<\/span><\/li>\n
  • 13-amino-acid N-terminal extension derived from porcine growth hormone<\/span><\/li>\n
  • Extended plasma half-life described in the literature (~20-30 hours vs. 12-15 min native IGF-1)<\/span><\/li>\n
  • Affinities for the IGF-1 receptor are conserved in in vitro models.<\/span><\/li>\n<\/ul>\n

    Signaling pathways described in the literature:<\/b><\/p>\n

      \n
    1. IGF-1R Receptor (tyrosine kinase):<\/b><\/li>\n<\/ol>\n
        \n
      • IRS-1\/IRS-2 activation documented in biochemical studies<\/span><\/li>\n
      • PI3K\/Akt\/mTORC1 cascade reported as the main protein synthesis pathway<\/span><\/li>\n
      • MAPK\/ERK1\/2 associated with cell proliferation in the literature<\/span><\/li>\n<\/ul>\n
          \n
        1. Reported cellular mechanisms (preclinical):<\/b><\/li>\n<\/ol>\n
            \n
          • Muscle satellite cell activation (Pax7+\/MyoD+) in murine models<\/span><\/li>\n
          • FOXO inhibition\/proteolytic atrophy documented in in vitro studies<\/span><\/li>\n
          • GLUT4-mediated glucose uptake in myocytes described in the literature<\/span><\/li>\n<\/ul>\n<\/details>\n
            \n\ud83d\udd2c DOCUMENTED SCIENTIFIC EVIDENCE<\/summary>\n

            The scientific literature documents IGF-1 and its analogs in multiple experimental models:<\/span><\/p>\n

              \n
            • Tomas FM et al., Endocrinology 1993 (PMID 8462469):<\/b> LR3-IGF-1 analogs in rat models showed anabolic effects on muscle protein synthesis<\/span><\/li>\n
            • Adams GR, Br J Sports Med 2002 (PMID 11916898):<\/b> Review documents the role of IGF-1 in muscle hypertrophy induced by mechanical overload<\/span><\/li>\n
            • Philippou A et al., In Vivo 2007 (PMID 17436567):<\/b> IGF-1 isoforms in post-exercise muscle repair in experimental models<\/span><\/li>\n
            • Frystyk J, Best Pract Res Clin Endocrinol Metab 2010 (PMID 20620540):<\/b> Review on IGF-1 Biology and Synthetic Analogs<\/span><\/li>\n<\/ul>\n

              Research material only. No FDA-approved human use. All information is provided for educational and scientific literature reference purposes.<\/i><\/p>\n<\/details>\n

              \n\u2697\ufe0f TECHNICAL SPECIFICATIONS<\/summary>\n
                \n
              • Identification:<\/b> IGF-1 LR3 (Long-R3 Insulin-like Growth Factor 1)<\/span><\/li>\n
              • Structure<\/b> 83 amino acids \u00b7 MW ~9,200 Da<\/span><\/li>\n
              • Modifications<\/b> Arg\u00b3 + N-terminal extension of 13 aa<\/span><\/li>\n
              • Vial<\/b> 1 mg lyophilized<\/span><\/li>\n
              • Purity<\/b> >98% by HPLC<\/span><\/li>\n
              • Conservation<\/b> refrigerated lyophilized 2-8\u00b0C \u00b7 reconstituted use within 28 days<\/span><\/li>\n<\/ul>\n<\/details>\n
                \n\ud83d\udccb RECOMMENDED USE<\/summary>\n

                Material intended exclusively for scientific research.<\/b><\/p>\n

                Not for human consumption. No FDA-approved human use. Information is provided for educational and reference purposes to the published scientific literature.<\/span><\/p>\n<\/details>\n

                Research material only.<\/strong> This product is intended for scientific research in controlled laboratory settings only. It is not a drug. Not for human or animal use<\/strong>, not for diagnostic or therapeutic use.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

                  \n
                • Synthetic analog of Insulin-Like Growth Factor 1 with Long-R3 extension that prolongs its plasma half-life for research.<\/li>\n
                • Used in studies of cellular proliferation, myogenesis, and muscle hypertrophy in experimental models.<\/li>\n
                • Supports research on PI3K\/Akt\/mTOR pathways, satellite cell differentiation, and tissue repair.<\/li>\n
                • 1 mg lyophilized vial \u00b7 high-purity compound \u00b7 for scientific research use only.<\/li>\n<\/ul>","protected":false},"featured_media":1934,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[39,38,40],"product_tag":[],"class_list":["post-1462","product","type-product","status-publish","has-post-thumbnail","product_cat-anti-aging","product_cat-body-recomp","product_cat-recovery","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"\nIGF-1 LR3 1mg - Elyxaminos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elyxaminos.com\/en\/product\/igf-1-lr3-1mg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IGF-1 LR3 1mg - Elyxaminos\" \/>\n<meta property=\"og:description\" content=\"An\u00e1logo sint\u00e9tico de Factor de Crecimiento Insul\u00ednico Tipo 1 con extensi\u00f3n Long-R3 que prolonga su vida media plasm\u00e1tica para investigaci\u00f3n. Utilizado en estudios de proliferaci\u00f3n celular, miog\u00e9nesis e hipertrofia muscular en modelos experimentales. Apoya investigaci\u00f3n de v\u00edas PI3K\/Akt\/mTOR, diferenciaci\u00f3n de c\u00e9lulas sat\u00e9lite y reparaci\u00f3n tisular. 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