{"id":1457,"date":"2026-05-26T08:16:39","date_gmt":"2026-05-26T13:16:39","guid":{"rendered":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/"},"modified":"2026-09-10T11:40:18","modified_gmt":"2026-09-10T16:40:18","slug":"5-amino-1mq-50mg","status":"publish","type":"product","link":"https:\/\/elyxaminos.com\/en\/producto\/5-amino-1mq-50mg\/","title":{"rendered":"5-Amino-1MQ 50mg"},"content":{"rendered":"<section>\n<h2>5-Amino-1MQ 50mg<\/h2>\n<p><strong>NNMT Inhibitor \u00b7 Preclinical NAD+ Rescue \u00b7 Research Only<\/strong><\/p>\n<h3>What is it and how does it work?<\/h3>\n<p>5-Amino-1-Methylquinolinium (5-Amino-1MQ) is a small molecule (non-peptide) \u2014 a selective, cell-permeable inhibitor of the NNMT enzyme (Nicotinamide N-Methyltransferase). The preclinical literature documents that NNMT blockade slows SAM and nicotinamide consumption, raising intracellular NAD+ and reactivating the salvage pathway, with effects in animal models on SIRT1 activity, lipolysis, lipogenesis suppression, and reactivation of senescent muscle stem cells.<\/p>\n<p>Primary preclinical evidence documented in rodents: Neelakantan H et al. (2018) Biochem Pharmacol 154:161-171 (PMID 29183836) \u2014 foundational study in high-fat-diet mice (DIO), 20 mg\/kg SubQ TID \u00d7 11 days \u2192 body weight reduction and white adipose mass loss without change in intake. Neelakantan H et al. (2019) Biochem Pharmacol 163:481-492 (PMID 30753815) \u2014 aged-muscle mouse model, NNMTi reactivated senescent muscle stem cells with +~70% peak torque in tibialis anterior. Research material only \u2014 no FDA-approved human use.<\/p>\n<h3>Reconstitution<\/h3>\n<ul>\n<li><strong>Vial<\/strong> 50 mg lyophilized<\/li>\n<li><strong>Bacteriostatic water:<\/strong> 2 ml (tablet \u2014 standard rule would be 10 ml, doesn't fit in 3ml vial)<\/li>\n<li><strong>Resulting concentration:<\/strong> 25,000 mcg\/ml<\/li>\n<li><strong>Per unit U-100:<\/strong> 250 mcg \u00b7 verification: 25,000 \u00f7 100 = 250 mcg\/u \u2713<\/li>\n<li><strong>Conservation<\/strong> Refrigerate 2\u20138\u00b0C \u00b7 Use within 28\u201330 days after reconstituting<\/li>\n<li><strong>Performance<\/strong> Equivalent volume: 200 U-100 units per reconstituted vial<\/li>\n<\/ul>\n<h3>Documented evidence in research literature<\/h3>\n<details>\n<summary><strong>Preclinical evidence \u00b7 obesity and body composition<\/strong><\/summary>\n<ul>\n<li>Neelakantan H et al., Biochem Pharmacol 2018 (PMID 29183836) \u2014 DIO model in male C57BL\/6J mice, NNMTi 5-Amino-1MQ 20 mg\/kg SubQ TID \u00d7 11 days \u2192 \u2193 body weight and \u2193 white adipose mass<\/li>\n<li>No significant changes in caloric intake reported \u2014 the effect is attributed to direct metabolic modulation, not anorexic<\/li>\n<li>Mouse\u2192human allometric conversion (km 3 vs 37): 20 mg\/kg mouse \u2248 1.6 mg\/kg HED \u2014 theoretical translational reference only<\/li>\n<\/ul>\n<\/details>\n<details>\n<summary><strong>Preclinical evidence \u00b7 sarcopenia and muscle repair<\/strong><\/summary>\n<ul>\n<li>Neelakantan H et al., Biochem Pharmacol 2019 (PMID 30753815) \u2014 NNMTi reactivated senescent muscle stem cells in aged mice<\/li>\n<li>Documented improvement: ~70% peak tibialis anterior torque in an aged mouse model<\/li>\n<li>Reported mechanism: rescue of the intracellular NAD+ pool by blocking NNMT<\/li>\n<\/ul>\n<\/details>\n<details>\n<summary><strong>Revisiones de mecanismo NAD+\/NNMT<\/strong><\/summary>\n<ul>\n<li>Roberti A et al. (2021) Front Endocrinol PMC8337113 \u2014 review &#8216;Roles of NNMT in Obesity and Type 2 Diabetes&#8217;<\/li>\n<li>Campagna R et al. (2024) Int J Mol Sci PMC11205546 \u2014 review &#8216;NNMT: A New Hope for Treating Aging and Age-Related Conditions&#8217;<\/li>\n<li>Modelo molecular: inhibici\u00f3n selectiva NNMT \u2192 \u2191 SAM intracelular + \u2191 nicotinamida \u2192 reactivaci\u00f3n salvataje NAD+ \u2192 \u2191 actividad SIRT1<\/li>\n<\/ul>\n<\/details>\n<h3>Combinations reported in literature<\/h3>\n<ul>\n<li>5-Amino-1MQ + MOTS-C in preclinical literature: independent mitochondrial pathways \u2014 NNMTi rescues NAD+, MOTS-C activates AMPK and mitochondrial biogenesis. No mechanistic overlap.<\/li>\n<li>5-Amino-1MQ + Tesamorelin\/CJC-Ipa: independent axes in research \u2014 GH\/IGF-1 vs metabolic modulation via NAD+\/SIRT1.<\/li>\n<li>5-Amino-1MQ + AOD 9604: lip\u00f3lisis directa (AOD) + bloqueo de lipog\u00e9nesis y rescate energ\u00e9tico (NNMTi) en modelos animales.<\/li>\n<li>5-Amino-1MQ + injectable NAD+: the literature reports complementarity \u2014 NNMTi stops the leak via nicotinamide methylation; injectable NAD+ replenishes substrate.<\/li>\n<li>5-Amino-1MQ + Retatrutide in emerging literature: triple GLP\/GIP\/GCG agonism + NAD+\/SIRT1 metabolic modulation in body-composition research.<\/li>\n<\/ul>\n<h3>Practical notes<\/h3>\n<ul>\n<li>Small molecule \u2014 NOT a peptide. Stable quinolinium with high membrane permeability. 50 mg vial compressed to 2 ml due to the physical limit of the 3 ml vial \u2014 concentration 25,000 mcg\/ml.<\/li>\n<li>Primary preclinical literature used SubQ administration in mice (Neelakantan 2018, 2019). Commercial guides typically cite oral administration for volume practicality in small mammals.<\/li>\n<\/ul>\n<h3>Contraindications and precautions<\/h3>\n<ul>\n<li>Research material only. No FDA-approved human use. All evidence is preclinical (mouse). No established long-term human safety data. Not for human use.<\/li>\n<\/ul>\n<p><em><strong>Research material only. No FDA-approved human use.<\/strong> This product is intended for scientific research purposes in controlled laboratory settings only. It is not a drug. Not for human or animal administration, therapeutic use, or diagnostic use.<\/em><\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p><strong>NNMT Inhibitor \u00b7 Preclinical NAD+ Rescue \u00b7 Research Only<\/strong><\/p>\n<ul>\n<li>5-Amino-1-Methylquinolinium (5-Amino-1MQ) is a small molecule (non-peptide) \u2014 a selective, cell-permeable inhibitor of the NNMT enzyme (Nicotinamide N-Methyltransferase).<\/li>\n<li>The preclinical literature documents that NNMT blockade slows SAM and nicotinamide consumption, raising intracellular NAD+ and reactivating the salvage pathway, with effects in animal models on SIRT1 activity, lipolysis, lipogenesis suppression, and reactivation of senescent muscle stem cells.<\/li>\n<li><strong>Presentation<\/strong> 50 mg lyophilized lyophilized \u00b7 <strong>For research purposes only<\/strong><\/li>\n<\/ul>\n<p><!-- ELYX-CERT-BUTTONS:start --><\/p>\n<div style=\"display: flex;flex-wrap: wrap;gap: 8px;justify-content: center;margin-top: 16px;margin-bottom: 8px\">\n<a href=\"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/05\/5AMINO1MQ_50MG_COA.pdf\" target=\"_blank\" rel=\"noreferrer\"><button style=\"display: flex;align-items: center;justify-content: center;background: linear-gradient(264.62deg, #02042B 11.77%, #0334D8 62.3%, #48DFE4 91.88%);padding: 12px 24px;border-radius: 50px;color: white;border: none;font-weight: bold;cursor: pointer;text-align: center;font-family: sans-serif;min-width: 130px\">Certificate of Analysis<\/button><\/a><br \/>\n<a href=\"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/05\/5AMINO1MQ_50MG_ENDO.pdf\" target=\"_blank\" rel=\"noreferrer\"><button style=\"display: flex;align-items: center;justify-content: center;background: linear-gradient(264.62deg, #02042B 11.77%, #0334D8 62.3%, #48DFE4 91.88%);padding: 12px 24px;border-radius: 50px;color: white;border: none;font-weight: bold;cursor: pointer;text-align: center;font-family: sans-serif;min-width: 130px\">Endotoxins<\/button><\/a>\n<\/div>\n<p><!-- ELYX-CERT-BUTTONS:end --><\/p>","protected":false},"featured_media":1929,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[37,41],"product_tag":[],"class_list":["post-1457","product","type-product","status-publish","has-post-thumbnail","product_cat-fat-loss","product_cat-metabolic-health","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>5-Amino-1MQ 50mg - Elyxaminos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/elyxaminos.com\/en\/product\/5-amino-1mq-50mg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"5-Amino-1MQ 50mg - Elyxaminos\" \/>\n<meta property=\"og:description\" content=\"Inhibidor NNMT \u00b7 Rescate NAD+ precl\u00ednico \u00b7 Research Only 5-Amino-1-Metilquinolinio (5-Amino-1MQ) es una mol\u00e9cula peque\u00f1a (no p\u00e9ptido) \u2014 inhibidor selectivo y permeable de la enzima NNMT (Nicotinamida N-Metiltransferasa). La literatura precl\u00ednica documenta que el bloqueo de NNMT frena el consumo de SAM y nicotinamida, elevando NAD+ intracelular y reactivando la v\u00eda de salvataje, con efectos en modelos animales sobre actividad SIRT1, lip\u00f3lisis, supresi\u00f3n de lipog\u00e9nesis y reactivaci\u00f3n de c\u00e9lulas madre musculares senescentes. 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La literatura precl\u00ednica documenta que el bloqueo de NNMT frena el consumo de SAM y nicotinamida, elevando NAD+ intracelular y reactivando la v\u00eda de salvataje, con efectos en modelos animales sobre actividad SIRT1, lip\u00f3lisis, supresi\u00f3n de lipog\u00e9nesis y reactivaci\u00f3n de c\u00e9lulas madre musculares senescentes. Presentaci\u00f3n: 50 mg liofilizado liofilizado \u00b7 para investigaci\u00f3n \u00fanicamente  COA Endotoxins","og_url":"https:\/\/elyxaminos.com\/en\/product\/5-amino-1mq-50mg\/","og_site_name":"Elyxaminos","article_modified_time":"2026-09-10T16:40:18+00:00","og_image":[{"width":1024,"height":1024,"url":"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/05\/5-Amino-1MQ-50mg-front-1024x1024.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/","url":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/","name":"5-Amino-1MQ 50mg - Elyxaminos","isPartOf":{"@id":"https:\/\/elyxaminos.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/#primaryimage"},"image":{"@id":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/#primaryimage"},"thumbnailUrl":"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/09\/5-Amino-1MQ-50mg-v3.webp","datePublished":"2026-05-26T13:16:39+00:00","dateModified":"2026-09-10T16:40:18+00:00","breadcrumb":{"@id":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/#primaryimage","url":"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/09\/5-Amino-1MQ-50mg-v3.webp","contentUrl":"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/09\/5-Amino-1MQ-50mg-v3.webp","width":1920,"height":1920},{"@type":"BreadcrumbList","@id":"https:\/\/elyxaminos.com\/producto\/5-amino-1mq-50mg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Inicio","item":"https:\/\/elyxaminos.com\/"},{"@type":"ListItem","position":2,"name":"Tienda","item":"https:\/\/elyxaminos.com\/tienda\/"},{"@type":"ListItem","position":3,"name":"5-Amino-1MQ 50mg"}]},{"@type":"WebSite","@id":"https:\/\/elyxaminos.com\/#website","url":"https:\/\/elyxaminos.com\/","name":"Elyxaminos","description":"Your trusted store","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/elyxaminos.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product\/1457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/comments?post=1457"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/media\/1929"}],"wp:attachment":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/media?parent=1457"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product_brand?post=1457"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product_cat?post=1457"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product_tag?post=1457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}