{"id":1455,"date":"2026-05-26T08:16:37","date_gmt":"2026-05-26T13:16:37","guid":{"rendered":"https:\/\/elyxaminos.com\/producto\/bpc-157-10mg\/"},"modified":"2026-07-27T09:32:53","modified_gmt":"2026-07-27T14:32:53","slug":"bpc-157-10mg","status":"publish","type":"product","link":"https:\/\/elyxaminos.com\/en\/producto\/bpc-157-10mg\/","title":{"rendered":"BPC-157 10mg"},"content":{"rendered":"<section>\n<h2>BPC-157 10mg<\/h2>\n<p><strong>Gastric Pentadecapeptide \u00b7 Angiogenesis \u00b7 Tendon and Ligament \u00b7 Research Only<\/strong><\/p>\n<h3>What is it and how does it work?<\/h3>\n<p>BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide derived from a protective sequence of human gastric juice. Preclinical literature describes multiple documented pathways of action in animal models: upregulation of VEGFR2 with an angiogenic effect, activation of the Akt-eNOS and Src-Caveolin-1-eNOS cascades on vasomotor tone, and an increase in growth hormone receptor in tendon fibroblasts with in vitro tenocyte proliferation (Hsieh et al., Sci Rep 2020 PMC7555539; Chang et al., J Appl Physiol 2011).<\/p>\n<p>Extensive preclinical evidence (Sikiric et al., University of Zagreb, since the 90s) in mouse and rat models: Achilles tendon healing, collateral ligament, gastric mucosa, intestinal anastomosis, and ulcerative colitis (PL-14736, Pliva Phase II trials). A systematic review from 2025 (Vasireddi et al., Am J Sports Med 2025 PMID 40756949) of 36 studies documents reduction in pro-inflammatory cytokines and modulation of tissue repair pathways in experimental models. No human use approved by FDA \u2014 research material only.<\/p>\n<h3>Reconstitution and dosage<\/h3>\n<ul>\n<li><strong>Vial<\/strong> 10 mg lyophilized<\/li>\n<li><strong>Bacteriostatic water:<\/strong> 2 ml (standard rule: 1ml per 5mg)<\/li>\n<li><strong>Resulting concentration:<\/strong> 5,000 mcg\/mL<\/li>\n<li><strong>Per unit U-100:<\/strong> 50 mcg \u00b7 verification: 5,000 \u00f7 100 = 50 mcg\/u \u2713<\/li>\n<li><strong>Conservation<\/strong> Refrigerate at 2\u20138\u00b0C \u00b7 Use within 28\u201330 days<\/li>\n<li><strong>Performance<\/strong> Equivalent volume: 200 U-100 units per reconstituted vial<\/li>\n<\/ul>\n<h3>Volume Conversion Chart (U-100 syringe)<\/h3>\n<table border=\"1\" cellpadding=\"6\" cellspacing=\"0\" style=\"border-collapse: collapse;width: 100%\">\n<thead>\n<tr>\n<th style=\"background-color: #02042B;color: white;padding: 8px\">U-100 equivalent<\/th>\n<th style=\"background-color: #02042B;color: white;padding: 8px\">Volume<\/th>\n<th style=\"background-color: #02042B;color: white;padding: 8px\">Load (mcg)<\/th>\n<th style=\"background-color: #02042B;color: white;padding: 8px\">Verification<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 6px\">5 u<\/td>\n<td style=\"padding: 6px\">0.05 mL<\/td>\n<td style=\"padding: 6px\">250 micrograms<\/td>\n<td style=\"padding: 6px\">5 u \u00d7 50 mcg = 250 mcg \u2713<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 6px\">10 units<\/td>\n<td style=\"padding: 6px\">0.10 mL<\/td>\n<td style=\"padding: 6px\">500 mcg<\/td>\n<td style=\"padding: 6px\">500 mcg<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 6px\">15 years old<\/td>\n<td style=\"padding: 6px\">0.15 milliliters<\/td>\n<td style=\"padding: 6px\">750 mcg<\/td>\n<td style=\"padding: 6px\">750 mcg<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 6px\">20 u<\/td>\n<td style=\"padding: 6px\">0.20 mL<\/td>\n<td style=\"padding: 6px\">1,000 mcg<\/td>\n<td style=\"padding: 6px\">20 units \u00d7 50 mcg = 1,000 mcg \u2713<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Documented evidence in research literature<\/h3>\n<details>\n<summary><strong>Preclinical Evidence \u00b7 Tendon and Ligament Healing<\/strong><\/summary>\n<ul>\n<li>Staresinic et al., J Orthop Res 2003 \u2014 rat Achilles tendon transected, 10 mcg\/kg IP\/PO \u2192 accelerated healing<\/li>\n<li>Krivic et al., J Orthop Res 2006 (PMID 16583442) \u2014 Tendon-bone detachment model, BPC-157 rescues healing and counteracts deleterious effect of corticosteroids<\/li>\n<li>Cerovecki et al., J Orthop Res 2010 \u2014 medial collateral ligament tear in rats; BPC-157 improves ligament healing<\/li>\n<li>Vasireddi et al., Am J Sports Med 2025 (PMID 40756949) \u2014 systematic review of 36 preclinical studies confirms modulation of pro-inflammatory cytokines<\/li>\n<\/ul>\n<\/details>\n<details>\n<summary><strong>Preclinical evidence \u00b7 gastric and GI mucosa<\/strong><\/summary>\n<ul>\n<li>Sikiric et al., Inflammopharmacology 2006 \u2014 PL-14736 (BPC-157) in early phase II trials for ulcerative colitis (Pliva, Croatia) in animal and exploratory human models<\/li>\n<li>Multiple models of gastritis, esophagitis, and intestinal mucosal damage documented protection and repair in rodents<\/li>\n<li>Typical preclinical ranges: 10 mcg\/kg\u201310 \u00b5g\/kg intraperitoneal or subcutaneous administration<\/li>\n<\/ul>\n<\/details>\n<details>\n<summary><strong>Documented molecular mechanism<\/strong><\/summary>\n<ul>\n<li>Hsieh et al., Sci Rep 2020 PMC7555539 \u2014 Src-Caveolin-1-eNOS activation in vitro<\/li>\n<li>Sikiric et al., Curr Pharm Des 2018 (PMID 29737246) \u2014 bidirectional modulation of the NO\/L-arginine system<\/li>\n<li>Chang et al., J Appl Physiol 2011 \u2014 upregulation of GH receptor in tendon fibroblasts<\/li>\n<li>Structural stability reported under gastric conditions\u2014property used as justification for oral exploration in preclinical studies<\/li>\n<\/ul>\n<\/details>\n<h3>Combinations reported in literature<\/h3>\n<ul>\n<li>BPC-157 + TB-500 (preclinical literature \u2018Wolverine\u2019 stack): independent pathways \u2014 BPC-157 via VEGFR2\/eNOS contributes to angiogenesis; TB-500 (Ac-SDKP sequence) contributes to cell migration. No reported mechanistic redundancy.<\/li>\n<li>BPC-157 + Tesamorelin\/CJC-Ipa in regeneration studies: endogenous GH amplifies GH receptor upregulation that BPC-157 produces in tendon fibroblasts in experimental models.<\/li>\n<li>BPC-157 + GHK-Cu: act on different compartments according to the literature\u2014BPC-157 in deep tissue (tendons, ligaments, mucosa); GHK-Cu in skin, fascia, and the extracellular matrix.<\/li>\n<li>BPC-157 + KPV: Both modulate anti-inflammatory pathways via distinct mechanisms in preclinical models\u2014KPV via melanocortin MC1R; BPC-157 via NO\/cytokines.<\/li>\n<\/ul>\n<h3>Practical notes<\/h3>\n<ul>\n<li>Presentation 10mg allows for extended research without frequent vial replacement. Vial yield: 200 units total U-100.<\/li>\n<li>Documented via primary preclinical literature: SC and IP in rodents. Reported gastric stability also allows for oral exploration in preclinical studies.<\/li>\n<\/ul>\n<h3>Contraindications and precautions<\/h3>\n<ul>\n<li>Research material only. Not FDA-approved for human use. No established human safety data. Preclinical literature reports theoretical caution in models with active cancer due to VEGF upregulation. Do not use in humans.<\/li>\n<\/ul>\n<p><em><strong>Research material only. Not approved for human use by the FDA.<\/strong> This product is intended for scientific research purposes in controlled laboratory settings only. It is not a drug. Not for human or animal administration, therapeutic use, or diagnostic use.<\/em><\/p>\n<p style=\"margin-top:16px\"><strong>Research material only.<\/strong> It is not a medication. <strong>Not for human or animal use<\/strong>, not for diagnostic or therapeutic use.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p><strong>Gastric Pentadecapeptide \u00b7 Angiogenesis \u00b7 Tendon and Ligament \u00b7 Research Only<\/strong><\/p>\n<ul>\n<li>BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide derived from a protective sequence of human gastric juice.<\/li>\n<li>Preclinical literature describes multiple pathways of action documented in animal models: upregulation of VEGFR2 with an angiogenic effect; activation of the Akt-eNOS and Src-Caveolin-1-eNOS cascades on vasomotor tone; and an increase in the growth hormone receptor in tendon fibroblasts with in vitro tendinocyte proliferation (Hsieh et al., Sci Rep 2020 PMC7555539; Chang et al., J Appl Physiol 2011).<\/li>\n<li><strong>Presentation<\/strong> 10 mg lyophilized lyophilized <strong>For research purposes only<\/strong><\/li>\n<\/ul>\n<p><!-- ELYX-CERT-BUTTONS:start --><\/p>\n<div style=\"display: flex;flex-wrap: wrap;gap: 8px;justify-content: center;margin-top: 16px;margin-bottom: 8px\">\n<a href=\"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/05\/BPC157_10MG_COA.pdf\" target=\"_blank\" rel=\"noreferrer\"><button style=\"display: flex;align-items: center;justify-content: center;background: linear-gradient(264.62deg, #02042B 11.77%, #0334D8 62.3%, #48DFE4 91.88%);padding: 12px 24px;border-radius: 50px;color: white;border: none;font-weight: bold;cursor: pointer;text-align: center;font-family: sans-serif;min-width: 130px\">Certificate of Analysis<\/button><\/a><br \/>\n<a href=\"https:\/\/elyxaminos.com\/wp-content\/uploads\/2026\/05\/BPC157_10MG_ENDO.pdf\" target=\"_blank\" rel=\"noreferrer\"><button style=\"display: flex;align-items: center;justify-content: center;background: linear-gradient(264.62deg, #02042B 11.77%, #0334D8 62.3%, #48DFE4 91.88%);padding: 12px 24px;border-radius: 50px;color: white;border: none;font-weight: bold;cursor: pointer;text-align: center;font-family: sans-serif;min-width: 130px\">Endotoxins<\/button><\/a>\n<\/div>\n<p><!-- ELYX-CERT-BUTTONS:end --><\/p>","protected":false},"featured_media":1542,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[40],"product_tag":[],"class_list":{"0":"post-1455","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-recovery","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product\/1455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/comments?post=1455"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/media\/1542"}],"wp:attachment":[{"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/media?parent=1455"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product_brand?post=1455"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product_cat?post=1455"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/elyxaminos.com\/en\/wp-json\/wp\/v2\/product_tag?post=1455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}