Tesamorelin 20mg

Tesamorelin 20mg

GHRH Analog · Visceral Fat · Endogenous IGF-1 · Research Only

What is it and how does it work?

Tesamorelin is a stabilized synthetic analog of human growth hormone releasing factor (GHRH). It binds to the GHRH-R receptor on pituitary somatotropes and stimulates pulsatile release of endogenous growth hormone, with documented increase in serum IGF-1 in clinical studies. The literature describes a preferential effect on visceral abdominal adipose fat in HIV-associated lipodystrophy cohorts.

Clinical evidence: Falutz et al. (NEJM 2007, PMID 17984164) in patients with HIV-associated lipodystrophy documented 15-20% visceral fat reduction with 2 mg/day SubQ × 26 weeks. Stanley et al. (JCI 2014, PMID 24911148) reported improvement of hepatic steatosis in non-alcoholic fatty liver disease. Research material only — no FDA-approved human use outside the specific indication of HIV lipodystrophy (Egrifta).

Reconstitution

• Vial 10 mg lyophilized
• Bacteriostatic water: 2 ml
• Resulting concentration: 10,000 mcg/ml
• Per unit U-100: 50 mcg · verification: 5,000 ÷ 100 = 50 mcg/u ✓
• Conservation Refrigerate 2–8°C · Use within 28–30 days after reconstituting

Documented evidence

• Falutz J et al., NEJM 2007 (PMID 17984164) — Tesamorelin 2mg/day SubQ × 26 weeks reduces visceral fat in HIV lipodystrophy
• Stanley TL et al., JCI 2014 (PMID 24911148) — Improvement of hepatic steatosis
• Adrian S et al., Clin Infect Dis 2018 — improvement in IGF-1 and body composition

Practical notes

• Route documented in clinical literature: SubQ once daily (typically at night)
• The effect on IGF-1 is dose-dependent; literature reports IGF-1 monitoring every 6-12 weeks
• Research stack: Tesamorelin + CJC/Ipa amplifies the GH axis; with BPC-157 for tissue regeneration

Contraindications and precautions

• Research material only. No FDA-approved human use outside Egrifta® for HIV lipodystrophy. No established safety data for other uses. Not for human use.

Research material only. No FDA-approved human use. This product is intended for scientific research purposes in controlled laboratory settings only. It is not a drug. Not for human or animal administration, therapeutic use, or diagnostic use.