Kisspeptin-10 10mg

Kisspeptin-10 10mg

HPG Activator · KISS1R Agonist · Pulsatile LH · Research Only

What is it and how does it work?

Kisspeptin-10 (KP-10) is the bioactive C-terminal fragment of the KISS1 gene product. It binds to the KISS1R (GPR54) receptor on hypothalamic GnRH neurons, triggering pulsatile GnRH release that stimulates LH and FSH secretion in neuroendocrine studies. The literature documents effects on LH/testosterone in animal models and in exploratory clinical trials of the HPG axis.

Documented evidence: Chan YM et al. (JCEM 2011, PMID 21632807) reported that IV boluses of 0.24 nmol/kg raise LH with a peak at 30-60 min in pharmacokinetic studies in healthy men as a functional axis diagnostic. George JT, Veldhuis JD et al. (Clin Endocrinol 2013, PMID 23153270) documented 4 mcg/kg/h × 11h infusion in exploratory studies. Comninos AN et al. (JAMA Netw Open 2023, PMID 36735255) reported sexual brain activation in functional research. Research material only — no FDA-approved human use.

Reconstitution

• Vial 10 mg lyophilized
• Bacteriostatic water: 2 ml (standard rule: 1ml per 5mg)
• Resulting concentration: 5,000 mcg/mL
• Per unit U-100: 50 mcg · verification: 5,000 ÷ 100 = 50 mcg/u ✓
• Conservation Refrigerate at 2–8°C · Use within 28–30 days
• Performance Equivalent volume: 200 U-100 units per reconstituted vial

Documented evidence in research literature

Combinations reported in literature

• KP-10 + HCG in PCT research literature: documented complementary pathways — KP-10 provides central hypothalamic stimulus; HCG directly mimics LH at Leydig cells.
• KP-10 + Tesamorelin: independent neuroendocrine axes in research — gonadal via KISS1R/GnRH + somatotropic via GHRH.
• KP-10 + PT-141: literatura reporta vías centrales distintas — KP-10 modula áreas hipotalámicas y cortezas asociadas (Comninos 2023); PT-141 activa receptores MC4.
• KP-10 + CJC/Ipamorelin in hormonal axis studies: optimization of the HPG + somatotropic axes in combined research.

Practical notes

• Mechanistic literature documents KISS1R desensitization with continuous exposure via β-arrestin (Jayasena et al.) — a pulsatile/intermittent regimen is what research reports.

Contraindications and precautions

• Research material only. No FDA-approved human use. No established chronic-use safety data. Not for human use.

Research material only. No FDA-approved human use. This product is intended for scientific research purposes in controlled laboratory settings only. It is not a drug. Not for human or animal administration, therapeutic use, or diagnostic use.