Cellular longevity is one of the most dynamic research areas of the decade. At its core are mitochondria and the compounds that
MOTS-C and NAD+ represent two complementary approaches to addressing ageing at the cellular level.
Why Are Mitochondria Key?
Mitochondria produce more than 90% of cellular energy (ATP). With ageing, their function declines: lower energy production, greater oxidative damage and accumulation of mutations in mitochondrial DNA.
This dysfunction is linked to type 2 diabetes, neurodegenerative diseases, sarcopenia and metabolic syndrome.
MOTS-C: The Mitochondrial Peptide
MOTS-C is a 16-amino-acid peptide encoded in mitochondrial DNA (12S rRNA gene). It is the first mitochondrial peptide that acts as a systemic signalling molecule.
| Mechanism | Description | Relevancia |
|---|---|---|
| Activación AMPK | Activates the energy-sensing kinase | Regulation of energy metabolism |
| Translocación nuclear | Migrates to the nucleus under metabolic stress | Regula expresión génica nuclear |
| Captación de glucosa | Aumenta absorción de glucosa muscular | Reversión de resistencia a insulina |
| Anti-senescencia | Protege células beta pancreáticas | Preservación función pancreática |
| Restauración muscular | Restores age-related muscle function | Contrarrestar sarcopenia |
Evidencia Clave
- Plasma levels decline with age and in type 2 diabetes, gestational diabetes and obesity.
- Revierte resistencia a insulina inducida por dieta alta en grasas (modelos animales).
- Exercise increases MOTS-C in skeletal muscle and systemic circulation.
- Previene senescencia de células beta pancreáticas.
- Sinergia documentada con agonistas GLP-1.
Análogo nueva generación: CB4211 has entered clinical trials for NASH and obesity, validating the mechanism.
Presentación Elyx: MOTS-C 40mg, pureza 98.6%.
NAD+: The Longevity Cofactor
NAD+ is an essential cofactor for more than 500 enzymatic reactions: energy production, DNA repair, epigenetic regulation and activation of sirtuins — the “longevity proteins”.
The Decline with Age
Levels fall ~50% between ages 40 and 60, correlated with mitochondrial dysfunction, DNA damage and chronic inflammation (inflammaging).
Funciones Clave
- Producción energética: Cofactor in the Krebs cycle and the electron transport chain.
- Sirtuinas: SIRT1-7 depend on NAD+. They regulate gene expression and DNA repair.
- Reparación ADN: PARP1 consume NAD+ como sustrato.
- Regulación circadiana: Participa vía SIRT1 y CLOCK/BMAL1.
Presentación Elyx: NAD+ 1000mg, purity >98%. Direct administration.
MOTS-C + NAD+: Sinergia
| Aspect | MOTS-C | NAD+ |
|---|---|---|
| Origin | Mitochondrial DNA peptide | Cofactor universal |
| Mechanism | Activación AMPK | Sustrato para sirtuinas y PARP |
| Energía | Optimiza metabolismo glucosa | Electron transport chain |
| Anti-edad | Previene senescencia celular | Activa longevidad (SIRT1-7) |
| Reparación ADN | Regulación indirecta | Sustrato directo PARP1 |
| Declive | Niveles plasmáticos bajan | Caída ~50% (40-60 años) |
| Pureza Elyx | 98.6% | >98% |
Conclusion
Mitochondrial health is the foundation of cellular longevity. MOTS-C and NAD+ address mitochondrial dysfunction from complementary angles.
At Elyx Aminos, both compounds are available with independent purity verification.
ELYX AMINOS
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