DSIP 5mg

DSIP (Delta Sleep Inducing Peptide) is a 9-amino-acid endogenous peptide discovered in 1977 from brain extracts of rabbits induced into deep sleep via electrical stimulation of the thalamus. Its name reflects the characteristic effect documented in the literature: the induction of delta or slow-wave sleep, the most restorative phase of the sleep cycle in research models.

Molecular structure:

• Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• Molecular weight: 848.8 Da
• Biological origin: endogenously produced in mammalian brain
• Half-life: 7 to 10 minutes in plasma (action mediated by downstream cascades)

• Hypothalamic-pituitary-adrenal axis modulation In research literature, a reduction in nocturnal cortisol release has been documented, associated with deeper sleep in models
• Increased cerebral adenosine: boost sleep homeostatic pressure
• Neurotransmitter Regulation balances acetylcholine, GABA, and glutamate in patterns favorable to deep sleep
• Endogenous antioxidant reduce neuronal oxidative stress accumulated during wakefulness
• Without direct action on melatonin or benzodiazepine receptors: Mechanism other than pharmaceutical hypnotics

• Chronic insomnia research, particularly deep sleep maintenance
• Studies on jet lag and circadian rhythm disorders
• Research in chronic fatigue syndrome
• Post-exercise recovery studies in high-performance models
• Chronic stress modulation research (via nocturnal cortisol suppression)
• Studies on sleep quality in abstinence contexts
• Preliminary studies in chronic migraine

Reconstitution: 2 ml of bacteriostatic water in a 10 mg vial. Resulting concentration: 5,000 mcg/ml. As a laboratory volumetric reference, each U-100 graduation corresponds to 50 mcg.

This data is provided solely as a handling and laboratory-bench calculation reference. It does not constitute an administration guideline.

In the research literature, DSIP presents a pharmacological profile described as benign: as an endogenous peptide, studies report no tolerance, dependence, or withdrawal syndrome in the evaluated models. Store lyophilized under refrigeration and, once reconstituted, protected from light.

• Sleep line + stress: DSIP along with Selank in nocturnal modulation studies
• Recovery line GH pulse research with DSIP, CJC No DAC, and Ipamorelin
• Cognitive line DSIP with Semax in day/night rhythm studies

1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977;74(3):1282-1286.
2. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83-93.
3. Sudakov KV, Ivanov VT, Koplik EV, et al. Delta-sleep inducing peptide (DSIP) as a factor facilitating animals’ resistance to acute emotional stress. Pavlov J Biol Sci. 1983;18(1):1-5.