Kisspeptin-10 5mg

Kisspeptin-10 is the shortest active form of the KISS1 gene product, a protein originally discovered in metastasis research (hence its name, derived from Hershey Kisses). The finding of its role as master regulator of the human reproductive axis came later and was revolutionary for reproductive endocrinology.

Molecular structure:

• Secuencia: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
• Molecular weight: 813.9 Da
• Vida media: 27 minutos aproximadamente
• Receptor: KISS1R (GPR54)

• Activación de neuronas GnRH: Kisspeptin binds KISS1R on GnRH-producing hypothalamic neurons, stimulating their pulsatile release
• Cascada gonadal: GnRH liberado activa hipófisis → LH y FSH → testículos u ovarios → testosterona, estrógeno, progesterona
• Restoration of the physiological axis: unlike exogenous TRT, kisspeptin works with the natural system, preserving pulsatile architecture
• Pulsatilidad mantenida: a critical mechanism for avoiding desensitization of the axis

• Functional hypogonadotropic hypogonadism
• Gonadal axis recovery after anabolic steroid use
• Investigaciones en infertilidad masculina y femenina
• Pubertad retrasada constitucional
• Hypogonadism associated with obesity or chronic stress
• Endogenous testosterone support in simultaneous use with other peptides

Reconstitution: 1 ml of bacteriostatic water in a 5 mg vial. Concentration: 5,000 mcg/ml.

Benign profile in research. Do not combine with exogenous TRT (defeats the purpose of the peptide). Monitor LH, FSH, total and free testosterone, and estradiol during the protocol. Relative contraindications: active hormone-dependent cancers.

• Kisspeptin + HCG for full gonadal axis recovery
• Kisspeptin + CJC No DAC + Ipamorelin para soporte hormonal integral

1. Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614-1627.
2. Dhillo WS, Chaudhri OB, Patterson M, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615.
3. George JT, Veldhuis JD, Roseweir AK, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab. 2011;96(8):E1228-1236.